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This study was a multi-center, open-label, 1-period study involving subjects who were categorized by their renal function as normal, and mild, moderate, or severe renal impairment, or as ESRD undergoing hemodialysis, based on estimated creatinine clearance (CLCR) by the Cockcroft Gault (CG) equation as described in the 2010 FDA guidance [ 7].
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The increased risk persisted in patients who recovered their renal function by the time of hospital discharge, but was less pronounced than the risk among patients without recovery of renal function.
Patients were classified according to their baseline renal function by calculating creatinine clearance (CLcr) values from baseline serum creatinine by the formula of Cockroft and Gault.
34, 35 For vancomycin, it was determined that 49% of the variability in clearance was explained by body weight, 18% by PMA, and 14% by renal function (as measured by serum creatinine concentration).
Treatment of type 2 diabetes is difficult in patients with chronic kidney disease because most oral antidiabetic agents are affected by renal function and their use may be contraindicated in this patient population.
Prescriptions were grouped by unit and antibiotic, then by renal function (normal, mild, moderate or severe impairment) or RRT, and by one of four categories (appropriate, underdosing, overdosing or incorrect regimen).
Plasma levels of Aβ are influenced by genetic factors and by aging and renal function.
Lending indirect support to the recorded left ventricular filling patterns is the fact that symptom severity as assessed by NYHA class also was unaffected by renal function (Table 1) [ 25].
The pharmacokinetics of 3TC is profoundly affected by impaired renal function.
The prognostic use of sUA differs by baseline renal function, suggesting different biologic and pathophysiologic significance of sUA among those with and without significant renal dysfunction.
While renal function may have impacted serum FABP7 levels, we attempted to adjust for this by including renal function (MELD) in multivariable analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com