Their molecular function was dominated by binding (50%), catalytic activities (31%), and cellular compartments were cell (43%) and organelle (31%).
Several studies have demonstrated that lncRNAs usually perform their molecular functions by binding to specific proteins (Maruyama, 2012).
A total of 24 genes (10 upregulated and 14 downregulated) differentiating paravertebral M1 and M2 transcriptomes were selected from group A and 11 genes (7 upregulated and 4 downregulated) from group B. Selected genes were subsequently classified by their GO molecular function through the open access PANTHER database (Table 4).
The renal clearance of proteins is limited by their molecular mass, hydrophobicity and kidney function, which is related to maturity [ 33].
This property might be used by these repeats to perform their elusive molecular function, be it related to DNA or to RNA metabolism.
Further analysis of the list of TNFα-regulated, MEK/ERK-dependent genes – whose products are found in the extracellular space – indicated that some of these genes were significantly categorized by the molecular function of their protein products into categories that included hyaluronic acid binding activity (including Agc1 and Hapln1) and proteinase activity (including Mmp-9 and Mmp-12).
In GO, the genes are categorized into different GO-terms in three ways: (a) by "biological process", (b) by "molecular function" and (c) by "cellular components".
The database is organised around genes, anatomical terms and developmental stages (see Materials and methods, GUDMAP entries) and can be queried by gene (via gene symbol), by anatomy (via anatomy term), by molecular function (via Gene Ontology annotation) and by accession ID for genes, probes and entries (MGI, Entrez, Ensembl, etc).
a classification by biological class; b classification by molecular function; c classification by protein class.
