Although chemoattractant GPCRs are mainly expressed by leukocytes and their major function has been considered as mediators of leukocyte trafficking and homing, over the past two decades, the role of GPCRs and their ligands in tumor progression began to be increasingly recognized.
Their major function is to maintain extracellular matrix (ECM) homeostasis.
Their major functions are to buffer replication associated shortening, and to protect chromosome ends from being processed as double stranded breaks by the cellular repair machinery.
Their major functions were in the cell cycle, cell junctions, and cell adhesion.
MSH6 mutations result in a weaker mutator phenotype (Kolodner et al, 1999), which may be explained by the major function of MSH6 to correct base base mismatches and single nucleotide deletion loops but not larger deletion loops (Parc et al, 2000).
It also lets the family reunite: We see Sarah in the kitchen, right after her new baby has been blessed in the church by Barb (a major function for a priesthood holder).
In addition to promoting folding of WT or ΔF508 CFTR by HSC/HSP70, a major function of DNAJs (Table 2) might in fact be to regulate degradation of ΔF508 CFTR.
In addition, an intuitional view was provided to understand their major molecular functions by six clusters from the clustering of these genes with themes in synaptic transmission, signal transduction, metabolic process, and apoptosis.
It is the control of motion that has traditionally been viewed by practitioners, and indeed intuitively by patients, as a major function of orthoses [ 35- 37].
The effect of miRNAs on their targets is reflected by the anti-correlated expression patterns between miRNAs and their mRNA targets because the major function of plant miRNAs is mRNA cleavage.
