Indomethacin and ibuprofen have a much higher potency for the inhibition of COX-1 than COX-2, as demonstrated by their IC50 value, with indomethacin being more potent than ibuprofen (Botting, 2006; Gierse et al., 1999).
The first two principal components for each set are shown in Figure 2, colored the points by their pIC50 values (Figure 2, and Additional file 1: Figures S1, S2, S3).
Cutting samples from Azadegan show significant pollution from migrating hydrocarbons, as shown by their S1 values which are higher than their S2 values, for a maturity lower than 430 °C T max.
As shown by their EC50 values, the order of specificity was hVIP (10.3 nM >hSCT (14.7 nM >xSCTAP273.15.6 nM)>xSCT (273.1 nM), which is in agreement with the cAMP assay.
Third, GGS_124 was the most virulent strain among 8 group G SDSE isolates, as determined by their LD50 values in a mouse infection model (Table 1).
In this report, we first demonstrated the heterogeneous sensitivity of 9 HCC cell lines to dasatinib in vitro as shown by their IC50 values.
We first examined the chain-length dependence of the potency of the foldamers, as assessed by their EC50 values in this assay (Table 1, top).
To create compound profiles, compounds that demonstrated activity in at least one cell type were clustered by their IC50 values across the 13 cell types.
Potentially, the true binding affinity is even better for these and the most potent compounds identified than is reflected by their IC50 values.
