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Breitling et al. proposed a simple method named GiGA which receives a list of genes ordered by their differential expression significance and extracts subnetworks corresponding to the most differentially expressed genes [31].
Germ cells and somatic cells were discriminated by their differential expression of vimentin [12] (vimentin is only expressed by somatic cells).
For instance, a frequently applied method is to score genes by their differential expression between two biological states (such as healthy vs. diseased).
Previously, we have reported that the osteoinductive and osteolytic potential in vivo of CaP and CaM cell lines can be defined in vitro by their differential expression not only of osteolytic cytokines, but also of the BMP antagonist noggin.
This notion is further supported by their differential expression across developmental stages [ 27, 28].
Clearly, eigengenes can be characterized by their differential expression patterns in different brain regions.
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While these may be pig specific, further analysis would be needed to confirm their biological relevance (for instance by testing their differential expression across tissues).
These results indicate that the activity difference of these three TFs between ER+ and ER- samples is at least partially caused by the their differential expression at the mRNA level.
These genes are probably not directly regulated by CRL1, but their differential expression in crl1 suggests that the lack of CR meristem differentiation may also induce fedback regulatory pathway acting on general TF and chromatin regulatory factors known to be involved in cell and meristem differentiation.
However, the plethora of Clds revealed by this study, their differential expression in the two types of CP and their age-related regulation suggest that there remain other so far undiscovered functions for some of these Clds.
Expression levels for 11 of these genes were compared by RT-PCR, and their differential expression between P7 and adult cerebellum confirmed.
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by their differential responsiveness
by their different expression
by their high expression
by their differential binding
by their differential adenylation
by their differential reaction
by their differential spread
by their differential dependency
by their differential content
by their differential accumulation
by their altered expression
by their differential staining
by their differential response
by their abnormal expression
by their differential detectability
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