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The level of PaCO2, which is completely controlled by the ventilatory settings in this sedated and sometimes paralyzed patient, is exposed to significant variations.
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A recent study conducted by de Durante and coworkers [ 4] demonstrated that the ventilatory settings employed in the ARDSNet low Vt group may generate an auto-PEEP of 5.8 ± 3 cmH2O.
This could be explained by the impairment of the host immune response, due to the lung injury and the ventilatory settings.
During the 13 min of fluid administration, there was no modification of the ventilatory settings.
A simple intervention on the ventilatory settings corrected the asynchronies in all the patients.
Overall the ventilatory settings were low however the FiO2, peak inspiratory pressures and use of a controlled mode of ventilation were significantly higher in the ≤2 hours group.
Overall, despite the absence of clinical studies that specifically address the ventilatory settings, it seems logical to maintain a PaCO2 within normal limits [9].
The ventilatory settings remained unchanged throughout the study period.
The ventilatory settings were adapted to the physiology of the sheep.
The ventilatory settings were returned to 6 ml/kg before fluid challenge.
The ventilatory settings were adjusted to achieve a tidal volume of 6 8 ml/kg/BW.
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