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We used a model based on the flow diagram in Figure 1 to quantify the amount of pharmaceuticals that reach the environment by the various pathways shown.
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However, it requires the commitment and the support of a broad community to construct an initial consensus network and to extend it with new knowledge from domain experts, the scientific literature, and as captured by the various pathway databases.
The first review by Reid and Duffield 2 examines the various pathways by which fatigue develops during match-play tennis.
Arrhythmias reflect the failure of the sinoatrial node, the normal cardiac pacemaker, to maintain a regular heartbeat, usually because of defects in the various pathways by which electrical impulses are carried to different areas of the heart.
To date, no study has attempted to provide links to the various pathways by which such integrins can be involved in these diverse disease settings.
Such findings highlight the need to uncover the various pathways by which the anterior thalamic nuclei and the hippocampus might conjointly support forms of biconditional learning.
In Creutzfeldt-Jakob disease (CJD) and other related transmissible spongiform encephalopathies it is critical to understand the various pathways by which the infectious agent spreads to different organs.
This paper looks beyond the evidence of the severe financial impact of ACS at the micro-level and attempts to map out the various pathways by which households experience CHE.
In this review we will discuss the various pathways by which the lipids that are required for lamellar body formation and stratum corneum function could also serve as signaling molecules and thereby coordinately regulate the formation of the stratum corneum (Fig. 2 ).
Future investigations using conditional knockout mice will be instrumental in identifying other targets of the miR-143/145 gene, to define in more depth the various pathways controlled by miR-143(145) in VSMCs.
In addition, this experimental/computational approach should permit the estimation of the fluxes in the various pathways (especially those less well known at the moment, such as the utilization of the reducing power produced by the serine/THF pathway in various cancer cells in vitro and possibly also in vivo).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com