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We used a Morris water maze scale and compared the degree of reversal of amnesia induced by the two agents.
Our mechanistic studies revealed that cooperative induction of DNA damage by the two agents and induction of Bim by VPA underlay the observed synergistic antileukemic activities of this drug combination.
The social cues signalled by the two agents will result in a response bias paralleling the strength of social cues, i.e. the more social cues are present the stronger the bias will be.
This notion is reinforced by the completely different IHC patterns presented by the two agents.
Several genes were affected in the same direction, but not to the same degree by the two agents.
This may be due to the different profiles of reactive oxygen species induced by the two agents.
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The representation facilitates retargeting to the robot by representing the two agents as kinematic chains with Denavit-Hartenberg parameters.
The value of this rationale is well illustrated by the examples of the two agents we have investigated here.
In contrast, the phosphorylation levels of Akt were reduced by the combination of the two agents.
Gefitinib either reduced or completely inhibited p42/p44 Erk kinase phosphorylation, depending on the cell line, while Akt phosphorylation was reduced by a combination of the two agents.
When the tumors reached approximately 200 mm, the mice were then treated with metformin (2 mg/ml) in the animals' drinking water, tamoxifen (60 mg/kg) by oral gavage, or the two agents simultaneously.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com