Sentence examples for by the total synthesis from inspiring English sources
The chirality of α-hydroxy-S230 was determined by the total synthesis of the relevant diastereomers.
The absolute stereochemistry was late confirmed by the total synthesis of -chimonanthine (Scheme 10).
Six new insulin analogues modified at the N-terminus of the B-chain have been prepared by the total synthesis and chain combination.
The preparative scale applicability of the method was demonstrated by the total synthesis of (S --hydroxymatairesinol (1) in 98% ee and 46% overall yield, S --hydroxymatairesinol5 (including itS --hydroxymatairesinol
Moreover, by combining enolate arylation with in situ functionalization, substituents can be rapidly and regioselectively introduced at the alkaloid C13 position, as demonstrated by the total synthesis of dehydrocorydaline.
These early biochemical investigations coincided with the development of solid-phase peptide synthesis (SPPS) by Merrifield (Scheme 1), a process that led to a tremendous surge in efficiency of oligopeptide preparation, as exemplified by the total synthesis of Ribonuclease S, a 124 residue protein.
The absolute stereochemistry of the new antifungal and antibacterial antibiotic produced by Streptomyces sp.201 has been established by achieving the total synthesis of the product.
Speculative fiction writer Simon Petrie writing in Andromeda Spaceways Inflight Magazine was impressed by the book's "grandiosity to the total synthesis of cosmology and myth", and Bear's "ability to encapsulate a universal future history in just the one book", but found the mix of science, fantasy, horror, mythology and religion a little "incongruous" at times.
This bis alkyne) could be readily deprotected under the controlled conditions used in the total synthesis reported by Wipf[ 15] to give the bis alkyne) alcohol 29.
One well-known and impressive application was reported by Nicolaou and co-workers in the total synthesis of the Calicheamicin γ1 where the high compatibility of 57 with other classical PGs and functions was demonstrated.
