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Missense variants were interpreted as likely deleterious if they were classified as deleterious or probably damaging by the three tools.
In addition, we predicted the interactions starting from miRNAs by the three tools of Targetscan [ 24], Pictar [ 38] and Tarbase [ 39].
To analysis the mRNA targets calculated by the three tools, we input each of 22 miRNA targets into DAVID bioinformatic tools.
In addition, we predicted the interactions starting from miRNAs by the three tools of Targetscan (Lewis et al., 2003), Pictar (Krek et al., 2005) and Tarbase (Sethupathy et al., 2006).
Comparing the PIPs detected by the three tools, START-PIPs were the most frequently rated as "non applicable".> -wrap-foot> aSexamplesles in Table 4 For the first time, this study described inappropriate prescribing and their determinants in a large representative sample of community-dwelling very old patients.
All the tandem mass spectra in the EC HCD and ETD data sets were deconvoluted by Decon2LS, MS-Deconv, and MS-Deconv+; the deconvoluted mass lists reported by the three tools were searched against the EC proteome for protein identification using MS-Align+ [ 15]. (See Additional file 1 for the parameter settings of MS-Align+ and the three tools).
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Three proteins in LT2 predicted to be positive T4S effectors by all the three tools meanwhile (STM1870, STM2074 and STM2256; Additional file 15: Table S8).
In this evaluation, we defined four indexes to compare the peaks identified by a particular tool and by combination of the three tools.
The proportion of individuals who were identified as having lymphedema by each of the three tools was identified and the Kappa measure of agreement was used to investigate the consistency of lymphedema identification.
The specificity and sensitivity attained by the transFIC of the three tools at separating highly recurrent from non-recurrent COSMIC mutations and recurrent from non-recurrent COSMIC mutations at each of these cutoffs are presented in Additional file 9.
A total of 73 peptide sequences were found to contain a GPI-anchor signal by at least one of the three tools (Additional File 1).
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