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(D ) The velocity dependence of motion anticipation was influenced by the synaptic density.
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250 synapses were found, corresponding to the synaptic density of 1.85 µm−3.
This might indicate that neurogranin reflects not the synaptic density but rather the intensity of current synaptic destruction.
However, unlike the transient synaptic depression elicited by leptin in juvenile hippocampus [ 45], leptin can increase the excitatory synaptic strength in adult hippocampus through preferential up-regulation of the cell surface expression of GluR1 and the synaptic density of GluR2-lacking AMPARs.
Figure 5 depicts the development of the synaptic density in control cultures and OXA treated cultures.
The synaptic density was determined separately for symmetric and asymmetric synapses according to DeFelipe et al. [ 32] (synaptic density = number of synapse-profiles in a given area / length of synaptic profiles).
These semiquantitative data were used to compare the synaptic densities between the different mouse lines.
Optimal brain function might also be compromised if the level of cholesterol in neurons drops below a threshold level, because when the cholesterol content of hippocampal neurons was decreased by statin treatment, synaptic density was reduced and synaptic vesicle release was impaired (Mailman et al., 2011).
These findings suggest that monotony during isolation contributes to early impairment in mood state by altering hippocampal synaptic density and neuronal morphology.
Caldendrin is localised to the post synaptic density of excitatory synapses [16] and integrates Ca2+ signals from both synaptic and extra-synaptic NMDA receptors to influence synaptic architecture [17].
Furthermore, the songbird nXIIts responds to androgen treatment by increasing the size of motoneuronal somata, synaptic density, and the number of synaptic vesicles [ 103, 104], which could increase their ability to drive vocalizations during the breeding season.
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