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We consider the scenario where the result of the information reception by the surface receptor initiates a signal transduction cascade in the receiver biological circuit.
The quantities p R (t, r, r R ) and p E (t, r, r R ) represent the concentration of the information molecules couples into the receiver by the surface receptor and surface enzymes, respectively.
Hence, while the received molecular signal within the space x → 0 is expressed by (14), the actual information concentration detected by the surface receptor antenna is expressed in (29).
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JAKs mediate signal transduction activity by the surface receptors for multiple cytokines.
This pathway is mediated by the surface receptors VEGF/NRP2 and α6β1 integrin, which activate FAK/Ras signalling culminating in the enhanced expression of GLI1 and the consequent induction of BMI-1 (Fig 9F).
Primary in vitro differentiated human mast cells (10) were sensitized with human myeloma IgE and exposed to test compounds for 24 hr, followed by activation of the surface receptor FcɛRI with anti-IgE.
Antibodies are Y-shaped proteins that neutralize virus particles by grabbing onto all the surface receptors they use to attach to cells.
PLG-bound spores were capable of exhibiting anti-opsonic properties by cleaving C3b molecules through the surface receptors α-enolase and EF-tu.
EcoHIV tropism to mouse cells is likely to be conferred not only by the cell surface receptor but also by the activity of the viral long terminal repeat (LTR), as is common for retrovirus replication in mice (Celander and Haseltine, 1984); EcoHIV encodes the HIV LTR.
As α-TOS exerts its proapoptotic activity via the distal, mitochondrial route, and TRAIL-induced cell death is relayed via the proximal pathway, triggered by the cell surface receptor engagement, we hypothesised that the two different modes of action could potentiate apoptosis in the TRAIL-resistant MM cells.
The coagulation cascade is initiated by the cell surface receptor tissue factor (TF), which is expressed constitutively by extravascular cells (pericytes, cardiomyocytes, smooth muscle cells, keratinocytes) and by vascular monocytes and endothelial cells upon induction by inflammatory cytokines or endotoxin [ 3].
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