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2) In Figure 2, I am surprised by the substantial variability of background uptake in the absence of the protein.
The management of patients presenting with metastatic malignant melanoma (MM) is hampered by the substantial variability in survival of these patients and the lack of prognostic markers.
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There are a few explanations available for the substantial variability between studies in sensitivity and specificity.
Cancer is a disease of the genome that is characterized by substantial variability in the clinical course, outcome, and response to therapies.
The current methods for mosquito age grading, i.e., ovary tracheation and dilatation [45], [46], [47], [48], fluorescent pigment quantity [49], cuticular hydrocarbon abundance [50], [51], and near-infrared spectroscopy [52], are problematic in determining the age of old mosquitoes by having substantial variability or limited application to multiple species.
Since single cells display a largely heterogeneous, multi-component cytoskeleton architecture, it is little surprising that they are often characterized by a substantial variability that only represents the multiple realizations of their internal polymer scaffold.
We did not find significant changes in proteinuria or C-reactive protein in our study, but this can probably be explained by the substantial intra-patient variability and small sample size.
Our 3D surface model of V1 averages over the observed substantial variability [8 10].
Nevertheless, it is clear that microarray hybridizations are affected by substantial variability even under controlled conditions.
The thresholds demonstrated substantial variability across the studies.
This complexity is compounded by the substantial morphological and temporal variability that often exists between different cells of the same type.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com