The discrepancy could be explained by the substantial difference in time scale of the comparisons, namely, between evolutionary time (in comparative genomics) and real time (in epidemiology).
The authors concluded that the self-sampling strategy could be cost-effective as compared with a reminder letter, as additional costs of the self-sampling strategy were offset by the substantial difference in participation [ 26].
The difference in the response between Int 407 and Caco-2 cells to LTD4 stimulation might be explained by the substantial difference in basal levels of gene expression between the two cell lines (Table 1A).
The large area of Brazil has a variety of climate zones: equatorial, tropical, semi-arid, highland tropical and subtropical, each one with different life style, in part determined by the contribution of different ethnical groups, part by the substantial differences in the industrialization degree and social development.
Also for this case, the differences in outcomes could be explained by the substantial differences in applied protocols and parameters measured [13], some of which bear resemblance to the protocols applied in this case of A. bipunctata (e.g., use of sugar solution and shorter exposure times).
The importance of tissue-specific mapping of posttranslational modifications of proteins is underscored by the substantial differences we find for lysine acetylation patterns across tissues.
The comparison of the impact of the 2003 heat wave between countries is hampered by the substantial differences in the methodologies employed to define heat wave events and to estimate the excess mortality [ 4, 6, 11- 13].
In the in vivo study by Netti et al (2000), the interpretation was complicated by the substantial differences in cell morphology, collagen organisation, and the lack of knowledge about the origin of the matrix material from tumour versus stromal cells.
The sensitivity of the NIRS technique to exercise intensity is remarkable, as evidenced by the substantial differences in muscle oxygenation observed when comparing straight-line vs. COD runs [ 35].
For the case of the unipath-based approach, the substantial difference can be explained by the multiple possible routes in which a given flow can be transmitted.
Considering the substantial difference, which is made by switching the effect estimates (HRs/ORs/RRs), these estimates will be analysed independently.
