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Suppose, he said, that a patient was available for a study, but was taking medication prohibited by the study protocol.
This variability is averaged out by the mean value from all subjects, because exact meal times were not prescribed by the study protocol.
Noninvasive blood pressure monitoring has been proven accurate in detecting MAP drops [17], and invasive monitoring via an arterial catheter was therefore not required by the study protocol.
Altered-pulse oximeters were employed to ensure that infants enrolled in the SUPPORT trial receive the treatment mandated by the study protocol by hindering neonatologists from adjusting the oxygen infants receive based on continuing assessments of their condition.
Over time, it became clear that subjects were part of a vulnerable population not adequately protected by the study protocol and from whom true informed consent was not obtained.
In summary, we were able to guarantee and to assure that laboratory data for the endpoint determinations as stipulated by the study protocol were reliable and of high quality.
We performed a second efficacy analysis (not specified by the study protocol) taking absence of abnormal activity in a diagnostic radioiodine scan as the sole criterion for successful ablation.
In the intervention group of those still breastfeeding at 4 months, 60.9% stopped breastfeeding by the completion of 4 months (as dictated by the study protocol) vs. 2.1% among the controls.
Treatment with any antidepressant was allowed by the study protocol.
A transthoracic echocardiogram was strongly recommended by the study protocol.
No medical interventions were required by the study protocol.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com