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We choose the top 10 most frequently located cellular compartments of the H. sapiens proteins that are targeted by the stringent and the conventional homology-based prediction approaches.
This table summarizes the number of informative GO terms annotated to proteins involved in PPIs predicted by the stringent and the conventional DDI-based approach.
Therefore, we focus on the top 839 PPIs respectively predicted by the stringent and the conventional DDI-based approaches and plot their percentage of PPIs having coherent informative GO terms in Figure 5.
We collect the known H. sapiens physical PPI dataset from MINT [ 13], BioGRID [ 14], and IntAct [ 15] as our gold standard PPI dataset to assess the H. sapiens PPIs predicted by the stringent and the conventional DDI-based approaches.
Then we plot the top 10 most frequently located informative CC terms for the targeted H. sapiens proteins by the stringent and the conventional homology-based approach in Figure 3 and Figure 4.
The precision-recall curves are plotted together for a better comparison in Figure 2. As the two PPI datasets predicted by the stringent and the conventional DDI-based approaches are very different in the number of PPIs, their precision-recall curves may not be sufficient for judging the performance of the two prediction approaches.
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tuberculosis H37Rv PPIN predicted by both the stringent and the conventional homology-based approaches.
Accumulation of uncharged tRNAs can be mitigated by the stringent response and ppGpp accumulation, which is perturbed in MC4100z1 [33], and prevented by chloramphenicol respectively [34], [35].
While industries and businesses around the world will welcome the various reductions in tariffs that accession will bring this summer, it is Russia's agreement to be bound by the stringent rules and dispute resolution mechanisms that will be the real game-changer over time.
The data indicate a dramatic reprogramming of protein synthesis in the non-growing state with many vegetative proteins repressed (e.g. by the stringent response) and others strongly induced (red labeled in Figure 2A) forming a complex adaptational protein network in order to face starvation and stress.
A limitation of the study is the small study population (in part caused by the stringent definitions of INRs and IRs) and the small number of outcomes, which did not allow us to extend the logistic regressions analysis or to calculate cause specific rate ratios of death.
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