Sentence examples for by the sterol synthesis from inspiring English sources

These included both the decrease in membrane cholesterol content by the sterol synthesis inhibitor mevastatin, and the decrease in membrane sphingolipid content by the sphingolipid synthesis inhibitor fumonisin.

For example, mice topically treated with the sterol synthesis inhibitor lovastatin have decreased epidermal sterol synthesis but increased fatty acid synthesis coincident with the development of an impaired permeability barrier [33].

Statins are inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the key enzyme of the sterol synthesis pathway.

Furthermore, the sterol synthesis-related mode of action of flusilazole toxicity was detected.

Additionally, the gene expression pattern suggests an imbalance in skin lipogenesis characterized by increased sterol synthesis but decreased fatty acid synthesis and alterations in fatty acid composition.

Overall, this gene expression pattern suggests that skin lipid synthesis is imbalanced in SKO mice, characterized by increased sterol synthesis and decreased fatty acid synthesis.

Its antifungal activity is achieved by preventing fungal membrane sterol synthesis through the inhibition of cytochrome P450 (CYP -dependent lanosterol CYP -dependentase conversion of lanosterol to ergosterol, resulting in an impairment of fungal cell replication.

The resistance of fungi was caused by multiple mechanisms including: 1) the mutation of the target protein encoding gene cyp51; 2) the over-expression of the target protein; 3) the up-regulation of transporting encoding genes such as MDR1, CDR1 and CDR2; 4) the mutation of sterol synthesis genes such as ERG3 which hindered the synthesis of sterol which is an essential component of membrane.

The expression of sterol synthesis genes erg2 and erg11 were regulated by CaUpc2.

The pathway of sterol synthesis has been thoroughly studied in vertebrates, fungi, and land plants (fig. 1).

Using the HXT1 promoter to control ERG9 expression, it was possible to divert the carbon flux from sterol synthesis towards α-santalene improving the productivity by 3.4 fold.