The virtual clay volume is represented by a spatial run-length encoding scheme.
It is frequently useful to represent physical processes by space-time diagrams in which time runs vertically and the spatial coordinates run horizontally.
The place cell sequences (templates) were calculated for each direction of the animal's movement and for each run session in all experimental conditions by ordering the spatial location of the place field peaks that were above 1 Hz.
We assumed here that, within a given simulation run, the spatial structure remains fixed across years.
Dotted line denotes average normalized spatial information during corresponding FamRun sessions used as reference for the spatial information during novel run sessions.
spacing indicates the spatial resolution for range (Ran).
Only on day 1 we observed a significant interaction between runs and schemas (F 3,50.1) = 3.9, P = 0.014; main effect of run: F 3.4,56.9) = 3.8, P = 0.011; main effect of schema: F 1,17) = 7.7, P = 0.013), which was caused by lower performance in the spatial as compared to non-spatial condition during the first run (t(21) = -3.2, P = 0.005; Figure 2A, left).
As can be seen, lower retrieval confidence for the spatial schema during the initial run of day 1 was also accompanied by lower retrieval performance and slower reaction times.
For each direction of run, preplay (i.e., pre-Run play) refers to an event's temporal sequence during pre-Run sleep/rest that has a significant correlation with the spatial cell sequence of the subsequent run session.
Spatial organization by the ran system might contribute to nuclear membrane recruitment by exposing DNA-binding domains of membrane proteins in the vicinity of chromatin but the relevance of such a mechanism has not been determined.
