In order to elucidate the genomic bases of the significant variability exhibited by environmental strains of the symbiotic phenotype, we sequenced the genomes of two strains of S. meliloti, AK83 and BL225C.
This notion was supported by the significant intersubject variability observed in the changes in protein levels in response to ULLS (data not shown).
The light touch and pin prick assessments made by the neurologist indicated significant variability in the transplant group, compared to the control group.
In all case studies that have been investigated, the distribution of soil moisture was characterized by a significant variability (difference between poorly and well-drained regions) of the soil tank.
Cancer is a heterogeneous disease caused by genomic aberrations and characterized by significant variability in clinical outcomes and response to therapies.
A recent assessment confirms this by showing significant variability between results obtained using different computational pipelines (SEQC/MAQC-III Consortium, 2014).
Elucidating this point is challenging, however: results obtained in experimental models are only partially applicable to humans, and information obtained in clinical trials is strongly affected by a significant variability in histological assessments and endoscopic follow-up protocols.
Expression of PyLT in the inducible cell lines was also examined by immunofluorescence, and significant variability in PyLT expression was observed in each clonal cell line upon AP treatment, ranging from background to very high levels (Figure 2B).
This was contributed to by small animal numbers and in particular by the significant between-animal variability in the younger cohort.
Voriconazole PK in older children and adults is characterised by significant variability in concentration time profiles and non-linear clearance [101].
