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The cerebral cortex is a complex laminated structure generated by the sequential migration of developing neurons from the ventricular zone.
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The sequential migration cost is less sensitive to the variation of the VM transfer capacity than the parallel migration cost, due to the similar behavior of the migration time and downtime as shown in Figure 8.
DC are highly mobile cells and by their sequential migration from peripheral tissues to lymphoid organs they serve as sentinels of the immune system.
In the following, two simple cases are considered: (i) when the M z VMs are transferred one at a time (sequential migration); (ii) when all the M z VMs are simultaneously transferred (parallel migration).
Comparing the two figures clearly shows that parallel migration has a more detrimental effect on the inter-DC network performance than sequential migration.
The interesting result here is that there is a value of b above which parallel migration becomes more convenient than sequential migration: according to the aforementioned definition of migration cost, this happens when the difference in terms of network overhead becomes less significant than the difference in application throughput degradation, which is reduced when adopting a parallel migration.
This is of relevance as sequential migration of neutrophils is stimulated by TNF-α induced inflammation and can be reduced by inhibition of Interleukin-6 secretion [ 21].
Figure 14 Sequential migration request blocking probability as a function of the arrival rate, for different values of the number of resource set instances supported by each remote DC. Figure 15 Parallel migration request blocking probability as a function of the arrival rate, for different values of the number of resource set instances supported by each remote DC.
Figure 12 Sequential migration request blocking probability as a function of the arrival rate, for different values of the number of resource set instances available per request.
Figure 6 Sequential migration request blocking probability as a function of the arrival rate, for different values of the total network pipe capacity.
Figure 18 Sequential migration request blocking probability as a function of the arrival rate, for different values of the large VM memory size multiplying factor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com