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Retinitis pigmentosa is characterized by the sequential loss of rod and cone photoreceptors.
This process operates by the sequential loss of the class of individuals in a population that have the highest fitness, resulting in an irrecoverable ratcheting up of the mutation load.
In the product ion mass spectrum (Fig. 3e), fragment ions at m/ z 352.1465 (B5), 324.1511 (C5), and 253.0775 (D5) were formed by the sequential loss of NH3, CO and amino-methylpropyl from the protonated molecule (Fig. 4).
Cellular senescence is characterized by cell-cycle arrest and alterations in cell shape and metabolism, and can be triggered either by the sequential loss of telomeres or by numerous forms of cellular stress, for example, UV irradiation, oxidative stress or aberrant oncogenic signaling (premature senescence).
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Our studies show the sequential loss of stress fibers during MOSE progression.
The development of the scales exploits the sequential loss of IADL and ADL functions.
The sequential loss of fluorescence from LY and TR was recorded relative to the timing of PKCε-YFP localization.
Moreover, the sequential loss of CH3 and CO or the loss of NH2CH3 can be used to discriminate between the protoberberine and aporphine alkaloids.
We define perforation of the Lm vacuole as the differential release of LY and TRDx; either by loss of LY only or by sequential loss of LY and then TRDx.
Fragment ion 2f is formed from the parent ion 2a (m/z 414; relative abundance, 21%) by sequential loss of CHCCl3 (2d, m/z 284; relative abundance, 10%), SO3 (2e, m/z 204; relative abundance, 28%) and HCl (2f, m/z 168; relative abundance, 100%).
One is via daughter ion 8b (m/z 183, 10%) by sequentially releasing HCl and chloroethyne, the other is via daughter ion 8g (m/z 217, 4%) by sequential loss of Cl2 and ethyne.
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