Overall, the changes induced by PICP in tumors are consistent with the sequential induction of gene expression reported in vitro.
Although the authors did not find direct evidence so far for malignant conversion of KAs into SCCs, the sequential induction of both tumour types by the same oncogene suggested common transformation mechanisms.
We suggest the sequential induction of Foxp3 and miR-155 by H. pylori keeps the cAMP pathway functional in order to achieve a long-lasting modulation of the immune system [45].
This experiment was designed to test between two possible mechanisms for the sequential induction of cleaning movements.
Adipocyte differentiation is characterized by marked changes in the pattern of gene expression that are achieved by sequential induction of various transcription factors [ 4].
Using insights from mammalian liver development, we developed a differentiation protocol to generate hepatocyte-like cells from hESC by sequential induction of primitive streak/mesendoderm/definitive endoderm, followed by gradual hepatic maturation.
We tested this possibility by examining the patterns of sequential induction of ROS-bZIP1 and representative subset of as1/ocs-like element-containing Group-II genes by integrating the qPCR expression profiles shown in Figures.
Two seemingly conflicting verbal models of vulval precursor cell fate specification have been proposed: sequential induction by the EGF-MAP kinase and Notch pathways, or morphogen-based induction by the former.
RA therefore mediates sequential induction of the Bhlh transcription factors Ngn3, Bhlhb2, and NeuroD that promote the generation of endocrine cells, followed by induction of the homeobox gene, Pax4, that determines β-cell identity, and finally the generation of insulin producing β-cells that express the homeodomain proteins Ipf1/Pdx1, Nkx6.1 and Hb9 (Fig. 4c).
Intestinal metaplasia occurs in a variety of settings, including induction by bile reflux, where it is also associated with induced COX-2, via the sequential transcriptional induction of SHP and CDX1 in precancerous lesions (Park et al. 2008).
