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Terminal differentiation of skin keratinocytes is a vertically directed multi-step process that is tightly controlled by the sequential expression of a variety of genes.
The various stages of NK cell development are characterized by the sequential expression of cell surface molecules.
The acquisition of immunological competence during ontogeny could partly be explained by the sequential expression of PRRs.
The maturation of muscle is coordinated by the sequential expression of myogenic regulatory factors, namely myoblast determination 1 (MyoD), myogenin and the muscle-specific regulatory factor 4 (MRF4; also known as Myf6).
Retinal progenitor cells progress through a series of competence states during development, giving rise to retinal cell type-specific precursors in a temporally restricted manner, a process which may be regulated at least in part by the sequential expression of retinal transcription factors (Ohsawa and Kageyama, 2008; Agathocleous and Harris, 2009).
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Interestingly, CupB5 gene is located in between CupB4 and CupB6 in CupB gene cluster (Figure 1A), and as shown by Fronzes et al, the sequential expression of a bacterial secretion gene cluster is essential for the formation and the stability of a multi-component complex in periplasm and outer membrane [28].
However, under our sampling scheme, we could not detect any differential expression of phase peaks among PpPRR1 to PpPRR4, similar to the sequential expression of phase displayed by the Arabidopsis quintet of PRR genes [Figure 2C, left panel; [ 60]].
In addition, peak expressions of O. sativa PRR37 and 73 are followed by expressions of PRP59 and 95, which may correspond to the sequential expression pattern of A. thaliana PRR7 and PRR5 [ 10, 13].
Cell-cycle phosphorylation is temporally ordered, at least in part, through the sequential expression of different cyclins.
Like the sequential expression of Bhlh genes (Fig. 3c), homeobox genes linked to β-cell differentiation were expressed in a sequential manner during RA-stimulated Ins+ cell differentiation.
Using the transfer function method, the sequential expression of the three genes can be simulated as shown in Figure 11 d).
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