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In silico analysis of 10 new canSNPs along this branch indicated that CDC 684 was not in the terminal node created by the sequenced Vollum strain, but rather was located in a node midway between the sequenced strain and a branch point defined by the initial analysis of 100 Vollum-like strains, Figure 1.
It also helps to understand the biological functions encoded by the sequenced DNA.
Despite the presence of partial gene clusters in groups B, C, D and E each group has remnants of different deletion events as indicated by the sequenced ends (Fig. 2).
For the initial heterogeneous populations, it is unclear which of the clones actually support infection and how much of the present variation is covered by the sequenced clones.
The amino-terminal sequence of each of these two proteins was determined, and compared with those predicted to be of proteins encoded by the sequenced genomes of S. epidermidis strains ATCC12228 [31] and RP62A [32].
Despite the tremendous achievements of 30 years of intensive research and the mass of information provided by the sequenced genomes in understanding the interactions between bacterial pathogens and their hosts, the molecular factors underlying host specificity of pathogenic bacteria still remain to be identified.
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The shock caused by the sequence was considerable at the time, and even now it seems audacious.
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Wisely, Brown does not let himself get hog-tied by the sequence of events in Dante's poem.
For each feature, we normalized by the sequencing depth of the corresponding chromosome to remove the impact of potential aneuploidies.
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