Sentence examples for by the sequence specificity from inspiring English sources

In mouse and human, PRDM9, a meiosis-specific H3K4me3 histone methyltransferase, recognizes the target sites by the sequence specificity and deposits H3K4me3 nucleosomes at meiosis recombination hotspots (Baudat et al., 2010).

One prediction of this hypothesis is that the disintegration reaction could demonstrate some sequence preference if integration, which must happen at a specific, defined site in the CRISPR locus, is partly driven by the sequence specificity of Cas1.

This may be partially explained by the sequence specificity of the STE20 primers.

In mice and human the hotspot locations are determined by the sequence specificity of the DNA binding domain of the PRDM9 protein [ 17- 19].

A TF binding site is usually 8to12-mer12-mere pair, determined by the sequence specificity and its physicochemical properties (structural and chemical properties), which are overlooked by both the PWM based and the k-mer based approaches.

The efficiency of the MABS technique was demonstrated by altering the sequence specificity of the bifunctional RE Eco57I from 5′-CTGAAG to 5′-CTGRAG, and thus generating the mutant restriction endonuclease (and DNA methyltransferase) of a specificity not known before.

However, clusterin expression was not affected by treatment with control ODN, suggesting the sequence specificity of the effect of OGX-011 on the clusterin expression in ACHN cells.

Initial studies by Vitkute et al., [14], predicted the sequence specificity of HP0593 MTase to be 5'-CTGCAG-3' (isospecific to PstI MTase), due to resistance to cleavage by PstI restriction enzyme.

Additional insight may come from the sequence specificity of uptake by species such as Haemophilus influenzae, where a 9 bp uptake signal sequence (USS) repeat is both highly overrepresented in the genome and needed for efficient DNA uptake.

Taken together, both the disintegration specificity and the deep sequencing data for integration support the hypothesis that integration is targeted to the leader-repeat 1 junction on the plus strand at least in part by the inherent sequence specificity of Cas1, which presumably involves specific recognition of these bases within the active site of the enzyme.

The mode of action of the DNA targeting ligands focuses either on the sequence-specificity by groove binding and strand cleavage, or by identifying the morphologically distinct higher order structures like that of the G-quadruplex DNA.