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Decay of LD is also greatly affected by the sequence diversity present in the samples used.
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This can be advocated by the fact that the sequence diversity is inversely proportional to the specificity of the GO terms.
In addition, while the antigen binding site of the γδ TCR is primarily formed from 3 CDRs contributed by each Vγ or Vδ domain, the sequence diversity in antigen receptors is highly concentrated in 1 or 2 CDR3s [9].
The sequence diversity created by transposon mutagenesis [= protein length – 1] is also more constrained than that created by incremental truncation [= (protein length – 1)×(protein length – 1)].
Thus, a proteomic analysis was performed to confirm the existence of predicted secreted proteins and evaluate the sequence diversity observed by in silico analysis at the protein level.
Here, we gain insight into the evolutionary history of HBD and its potential function in gene regulation by performing a detailed analysis of the sequence diversity and divergence of the β-globin cluster in humans and chimpanzees.
The majority of STs occurred as singletons so that although there was limited sequence diversity, as evident in very low π and θ values, suggesting that the sequence diversity was magnified by extensive intra-species recombination generating genotypes which can be readily distinguished by sequence analysis [58].
Thus, we then analyzed if the sequence diversity has been shaped by directional selection pressures.
Amplification of specific HIV genome regions is complicated by the high sequence diversity of the HIV genome.
We undertook a modular approach to primer design to retrieve cooS genes from environmental sources and overcome challenges presented by the broad sequence diversity of CODH enzymes and the semi-conserved nature of the cooS primer binding sites.
This is strengthened by the high protein sequence diversity among the L. infantum and L. major paralogs of Chr 12.
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