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Some generic engineering issues raised by nuclear fatigue analyses are here illustrated by the sensitivity analyses which have been performed.
Parameters, having a great impact on the net weight of reactor coolant system, were picked out as the design variables by the sensitivity analyses, and were optimized by means of genetic algorithm.
If future decreases in smoking prevalence are substantial, this could help to ameliorate the adverse impact of increased radon levels, as shown by the sensitivity analyses.
It is not supported by the sensitivity analyses, however, because the HR was lower (1.47) when patients with contralateral cancers were included.
The range of estimates for the median population prevalence of HCV produced by the sensitivity analyses was 2.15 to 2.83% (see Additional file 1: Appendix C).
Overall, the costs predicted by the sensitivity analyses were much higher than the base case, indicating an underestimation of true costs.
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By contrast, the sensitivity analyses in the present study indicated that temperature dependence in the spread of BTV between farms (in this case via a threshold temperature below which transmission was assumed not to occur) could impact on model predictions for the spread and control of BTV.
We obtained life expectancy from the actuarial tables provided by the US Social Security Administration [ 24], and this number was varied by 25% in the sensitivity analyses.
Our findings based on parametric modelling are considered to be robust as they were supported by results of the sensitivity analyses with the Kaplan Meier (non-parametric) estimation.
Daily use of bisphosphonates was associated with a decreased risk (0.60, 0.41 to 0.87; P=0.008) in CPRD, but this was not confirmed by any of the sensitivity analyses.
In CPRD data, short term use was associated with an increased risk, although this reached significance only for one to six months' use (1.27, 1.09 to 1.48; P=0.002), but this finding was not confirmed by any of the sensitivity analyses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com