Sentence examples for by the segmentation clock from inspiring English sources

Vertebrate segmentation is regulated by the "segmentation clock", which drives cyclic expression of several genes in the caudal presomitic mesoderm (PSM).

Somites are generated as epithelial spheres of cells that sequentially bud off at regular intervals from the anterior extremity of the presomitic mesoderm (PSM) in an anterior-to-posterior direction with a strict periodicity, which is controlled by the segmentation clock [2].

Thus, nascent Dll1 and Notch1 mRNA expression oscillates in the PSM in the manner of a clock gene and their transcription is therefore likely to be regulated by the segmentation clock.

Thus, the mechanisms by which the segmentation clock interacts with the gradient of signalling pathways in the PSM remain a mystery, despite great advances in the last few years.

The clock and wavefront mechanism is a generic proposal about the dynamics of the system and, regardless of the molecular details, at steady state the segment length is fixed by the period of the segmentation clock and the wavefront velocity (Gomez et al., 2008; Morelli et al., 2009; Oates et al., 2012).

We then studied the possible biological links of the top 300 genes predicted by each method to the segmentation clock process.

This periodicity is regulated by a molecular oscillator, known as the segmentation clock, that is defined by cyclic gene expression within PSM tissue with a period that regulates somite formation.

In vertebrates, the timing and spacing of formation of the mesodermal somites are controlled by a molecular oscillator termed the segmentation clock.

The present study implies that body elongation observed in Erpetoichthys seems to be brought about in an early phase of polypterid evolution, possibly by accelerating the tempo of the segmentation clock twice as fast as that in other polypterids.

In vertebrates, the timing and spacing of somite formation is controlled by a molecular oscillator termed the segmentation clock (Dequeant and Pourquie, 2008; Gibb et al., 2010; Lewis et al., 2009).

It is therefore expected that segment length and the segmentation clock period are closely related to the morphologically observable somite length and somitogenesis period, respectively.