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Two-thirds of the cancers, detected by the second reader only, were found by two radiologists.
Parallel scan inter-reader reproducibility is obtained by comparing scan 1 read by the first reader and scan 2 read by the second reader.
12/20 false positive TB-bead slides were confirmed as smear-positive by blinded re-checking of the magnetic bead-FM slides; the remaining 8 slides were reported as smear- negative by the second reader (Table 3).
The high precision in measurements by the second reader allowed us to select a 0.3 mm cutoff value, which is much lower than the 0.5 mm cutoff value usually recommended from previous studies [ 9, 11].
At double-reading, the two breast radiologists tended to have the best screening results with the highest sensitivities and the highest number of cancers detected by the second reader only, but otherwise we do not have a plausible explanation for this observation.
At double-reading, the two specialized breast radiologists (screener E and F) detected 67.6% (25/37) of the cancers found only by the second reader and they acquired the highest sensitivity values of 77.0% (95% CI=70.5 83.4) and 70.7% (95% CI=64.7 76.7), respectively.
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Validity and reliability was further established by the second readers' reviews, and the recognition that the emerging data in this study directly mirrored both the content and the gaps identified in the literature review.
She was probably not reassured by the first reader, Susan Cheever, who told fascinating stories about the "genius cluster" surrounding Ralph Waldo Emerson in Concord, Mass.
Parallel scan intra-reader reproducibility is obtained by comparing scan 1 read by the first reader and scan 3 read by the first reader.
In case of no consensus the final decision was made by the third reader, the principal investigator.
One interval cancer had initially been considered positive by the first reader, but had been assessed negative at consensus reading.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com