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When comparing response indices after the first to the ones after the second immunization in the PEV301 50 µg groups, the difference was borderline significant (p = 0.09) indicating that the initial response was possibly boosted by the second administration.
When comparing response indices after the first to the ones after the second immunization in the 10 µg group, the difference was borderline significant (p = 0.056) indicating that the initial response was boosted by the second administration.
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Saturation was also avoided by giving the second administration no earlier than 24 h after the priming activity.
Two weeks after drug administration, sCTX started to rise in both treatment groups, reaching −16% and −20% below baseline by day 84, ie, immediately before the second administration.
The second administration of the SIT-Q generated an estimate of total sedentary behavior that was 52 less than derived by the first administration.
Reliability of the tool was checked through an additional administration for 40 nurses at a time interval of 20 days by the first administration and tested using the weighted-kappa which showed satisfactory test-retest reliability for the questionnaire score (kappa scores >0.7).
The response to 5-HT showed some desensitisation; the peak response to 10 μM was reduced by 35.7 ± 7% (n = 21) in the second administration (Fig. 1Aiii).
Patients received a 240-mg loading dose of faldaprevir at the first administration followed by 120 mg QD thereafter.
The first administration was along the standard instructions as described by Heaton [ 18]; at the second test administration, one hour after the first one, the subjects were also required to 'verbally express' the matching criterion before the card sorting.
The ban was relaxed during the Clinton administration, but then reinforced by the second Bush administration in the run-up to the current hostilities in Iraq.
Since it was recast into its current form by the second Bush administration — and renamed No Child Left Behind — it has generated frequent, divisive debate, partly because it requires schools to administer far more standardized tests and because it labels schools that fail to make progress fast enough each year as "needing improvement".
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