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RNA degradation plots seemed to reflect to some extent the bimodality between samples types although individual variability was clearly larger than the variations caused by the sample type (see Figure 2).
Accurate and sensitive detection of viral RNA is also strongly influenced by the sample type.
Similar(58)
In the user-interface of the EOPM software, the proportion of probes can be chosen by the user according to the sample types.
More importantly, four microRNAs (miR-200a, miR-429, miR-375 and miR-222) were in common for the serum, plasma and the combined cohorts in their association with overall survival (P<0.05), indicating that these microRNAs are likely to be robust biomarkers that are not influenced by the blood sample type.
Differentially expressed genes by the four sample types were extracted by multiclass response test; threshold of the significantly regulated genes is Local-FDR < 1 %.
In the subgroup analysis by sample type, the associations between miR-155 expression level and breast cancer showed to be significant in both tissue and blood sample.
Pooled estimates of sensitivity and specificity for the analyses by sample type and smear status were calculated in Stata, using the bivariate random effects and random effects models, respectively [ 10].
This assay was previously validated in urine, in comparison to a gold standard sample (cervical liquid-based cytology sample or penile swab), by measuring the HPV concordance by sample type (Cuschieri et al, 2008).
When the results were pooled by sample type, the tissue tests showed a sensitivity of 100% and a specificity of 95%, and the plasma tests showed a sensitivity of 100% and a specificity of 98%.
Additional data from the investigation by sample type are provided in Table 6.
The main clustering in the left figure is eukaryote versus bacteria while the patterns in the right figure are more dominated by sample type with the eukaryote/bacteria samples mixed up.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com