Imperfect time synchronization, however, affects IA but this issue can be overcome by performing IA at the sample level, i.e., before demodulation and synchronization takes place.
As in our previous SNP microarray studies (Marshall et al. 2008; Pinto et al. 2010; Lionel et al. 2011), we defined a CNV as being 'stringent' if it was detected by both algorithms at the sample level.
After the initial alignment, processing is parallelised only by sample, and by parallelising selected independent operations at the sample level.
The 347 transcripts detected by the sample-level meta-analysis mapped to 125 fruit fly genes with GO information (Additional file 3).
Fourth, transcripts that were found differentially expressed in multiple individual studies and the study-level meta-analysis, but were not detected by the sample-level meta-analysis.
Of the 853 transcripts detected by the sample-level meta-analysis, 621 transcripts were not detected in at least two individual-study analyses, and 349 transcripts were not detected by any single individual-study analysis.
In terms of individual genes, among the 347 transcripts detected solely by the sample-level meta-analysis, two transcripts merit special attention because they are new to the list of genes associated with one-day-old and forager differences, and because of their known biological role.
Of the 351 transcripts, 347 transcripts were solely detected by the sample-level meta-analysis, two transcripts were solely detected by the study-level meta-analysis (identifiers BB160008A20A01, BB170022B20E11), and two additional transcripts (BB160014A10H01, BB170011B10F10) overlap between the study-level and sample-level meta-analyses.
Nagelkerke R is a corrected version of the Cox R that covers the range from 0 to 1. Table 1 shows the social and demographic characteristics of the sample by level of autonomy.
2) We describe the sociodemographic characteristics, economic circumstances and health status of the sample by levels of dependency.
The highest titer was shown by the sample that yielded positive levels of both IgM and IgG in the ELISA, which suggests recent WNV infection.
