Sentence examples for by the same prion from inspiring English sources

Variant Creutzfeldt-Jakob disease (vCJD) is a TSE caused by the same prion protein that causes Bovine Spongiform Encephalopathy (BSE) in cattle.

Molecular strain-typing studies and experimental transmission studies in mice published in 1996 and 1997 confirmed that vCJD is caused by the same prion strain that causes BSE (Collinge 1999).

Both isoforms are encoded by the same prion protein gene (PRNP), and the structural changes occur post-translationally. Certain mutations in the PRNP gene result in genetic TSEs or increased susceptibility to TSEs.

In addition, the lack of homogeneity in the clinicopathologic manifestation and codon 129 of the prion protein gene among the three patients suggested that their illnesses could not be explained by exposure to the same prion strain.

The weak [PSI+] phenotypes of some strains (e.g. A4) could be caused by weakened propagation of the same prion variant or by the formation of a different prion variant To test the possibility that different, structurally distinct, prion variants are generated in the presence of different Hsp70 orthologs, we focused on A1 and A4 that have normal and weak prion phenotypes, respectively (Figure 5A).

As positive controls for brain samples comprising a key disease aggregated protein, we also extracted by the same method homogenates of prion-infected brains, both from a transmissible 36 and for a genetic TgMHu2ME199K model.

By the same back.

Interestingly, three of these protein spots were subsequently identified as well-known markers for prion diseases 14-3-3 14-3-3 14-3-3and neuron-specific enolase) and two fourth aspotstand dehydrogenase, previously reported in sporadic CJD by thenolasegroup [ 47].

At the same time, transmissible prion disease could also be induced by recombinant PrP (rPrP) amyloid fibrils formed in vitro in the absence of any co-factors although at low efficiency [ 7– 12].

One gram of brain matter contains the same number of prions as thirty thousand gallons of urine.

Prion strains are infectious isolates that, when propagated in the same host, exhibit distinct prion disease phenotypes that persist upon serial transmission [8], [9], [10].