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Why the different three-dimensional wax morphologies co-exist on the surface of a single cell is unknown, as is whether these different morphologies are built up by phase separation of different compounds or if they are formed by the same compound.
In approximately 57% of the cases, kinases inhibited by the same compound are quite distant according to the sequence-based classification (distance 0.6 – 0.8), but rather close according to the bioactivity-based classification employed in the current work (distance 0 – 0.4).
In most cases, it is clear that there is a big cluster of data points on the left side of the y = x partition, meaning that kinases inhibited by the same compound are quite distant according to the sequence-based classification (distance 0.6 – 0.8), but rather close according to our fingerprint enrichment-based classification (distance 0 – 0.4).
Another remarkable advantage of inhibitors is that they can provide an opportunity to overcome functional redundancy since homologous proteins are often targeted by the same compound.
Therefore, discovering polypharmacological targets, share similar interfaces and are often inhibited by the same compound, is a valuable issue in understanding binding mechanisms and drug development.
Studies using rodents exposed to alkylating agents have demonstrated that phosphate adducts had half-lives longer than those of any other known DNA alkylation products formed by the same compound.
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Equilibrium controls were obtained by combining the same compound and buffer solutions without the presence of a membrane.
To report a series of patients with Streptococcus endophthalmitis after injection with intravitreal bevacizumab prepared by the same compounding pharmacy.
This mechanism is almost but not quite species specific, as it is possible for a few closely related bees to pollinate any given species of orchid, as long as the bees are similar in size and are attracted by the same compounds.
The difference cannot be explained by misfolding of the protein as both BsaS and YscN ATPases, with only 40% identity, were inhibited by the same compounds with a similar potency (Table 3).
For the 48-hr treatment of precursor cells, the proliferating cells were treated at confluence by the same compounds, at the same concentrations.
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by the same complex
by the same component
by the same combination
by the same academy
by the same composition
by the same substance
by the same route
by the same woman
by the same title
by the synthesized compound
by the isostructural compound
by the repetitive compound
by the heterozygous compound
by the same margin
by the same algorithm
by the chemical compound
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by the above compound
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com