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These domains are spatially defined by the restricted expression of members of the HD transcription factor family and the bHLH factor Olig2.
Notably, they were probably involved in shaping the medusa (clearly a modified body plan derived from within the cnidarians), as suggested by HOX1 gene expression in mechanosensory cells of the statocysts (in Clytia, figure 2P) or in striated muscular cells (in Podocoryne [24]), and by the restricted expression of Clytia CheMox in particular areas of the medusa gastro-vascular system.
It appears, therefore, that the effects of RA are controlled by the restricted expression of ALDH isoforms in small islands of epithelial or stromal cells.
Layer V was easily distinguishable by the restricted expression of SATB2 and concentrated expression of ER81 in this layer and the absence of expression of NURR1.
Sn seems thus a promising target for cell-directed therapy, a strategy that is further encouraged by the restricted expression pattern of Sn limiting unwanted side effects.
Dorso-ventral subdivision of the pallium by the restricted expression of Emx1/A may thus have been acquired before the divergence between cyclostomes and gnathostomes, as proposed previously [ 41].
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We validated the above by showing the restricted expression of HMGA2 only in primary TNBC samples and not in 'normal' breast tissue or in other breast cancer subtypes.
The expression of TAA1 as well as some TARs in roots and apical hooks of Arabidopsis seedlings can be induced by ethylene treatments and the restricted expression of TAA1/TAR genes leading to local IAA production is thought to be the basis of tissue-specific ethylene effects [ 58].
The PRE helps to maintain the restricted expression by the enhancer in older embryos.
The reduced expression area supported the data obtained by quantitative RT-PCR and further suggested that the restricted expression of RhAG caused by the low temperature treatments might promote the petaloidy of stamens, resulting in the formation of double flowers.
Taken together the in situ hybridization data confirm the restricted expression of BAMBI in endothelial cells noted by immunohistology and by the mRNA data with cultured endothelial cells.
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