The response defined by the three most significant parameters was obtained from full factorial design and the optimal parameter set was found.
We further tested this hypothesis in a mouse xenograft model by focusing on the tumor response defined by tumor regression to half of the size of the tumors at randomization.
The residues that yield high values of the energy response defined by Equation 6 are calculated according to the scheme outlined in the Methods section.
The febrile response, defined by Plaisance and Mackowiak, is a "complex physiologic reaction to disease involving a cytokine mediated rise in core temperature, generation of acute-phase reactants, and activation of numerous physiologic endocrinologic and immunologic systems" [ 15].
In this context, the importance of the electrohydraulic servovalve dynamic response, defined by the time constant, to ensure a reasonable parametric robustness of the control law, has been established.
With the PBMCs from those patients, we eventually validated the epitopes and the CD4+ T cell response defined by the experiments with transgenic mice.
The primary efficacy end point of the study was tumour response defined by the Response Evaluation Criteria in Solid Tumors (RECIST, Version 1.0; Thérasse et al, 2000).
Irrespective of the study's power, the efficacy end point of a 20% response defined by the ACR response criteria [ 9] with an ITT responder-at-end-point analysis was quite low and was without a clinically meaningful difference from that seen in the placebo group.
We test the hypothesis that the structure of a linear multi-stage phosphorylation cascade is the result of an optimization process aiming for a fast response, defined by the minimum of the product of signaling time and signal duration.
In the second case study described below, we combine quantitative data on microparasites carried by wild migrating salmon with a measure of host response defined by the transcriptional activity of a subset of immune- and stress-related genes to gauge which microbes may be associated with the most 'damage' to the host, hence potentially impacting performance of wild fish.
