Sentence examples for by the replication checkpoint from inspiring English sources

Mde2, whose expression is strictly regulated by the replication checkpoint, interacts with Rec15 to stabilize the SFT subcomplex and further binds Rec14 in DSBC.

These data suggest that the loading of specific DSB factors is prevented by the replication checkpoint.

Alternatively, the DSB factors may be directly regulated by the replication checkpoint.

Although the mechanism is yet unclear, circumstantial evidence suggests that Mcm2-7 is regulated by the replication checkpoint.

Alternatively, in meiotic cells under conditions of dNTP insufficiency, S-phase arrest is mediated by the replication checkpoint kinase Cds1 (Murakami & Nurse 1999).

This WRN function as fork protector could be regulated by the replication checkpoint preventing the disassembly of the replisome or providing enzymatic activities for the removal of certain DNA structures that stop fork movement.

These data confirm that MBF-dependent transcription is regulated by both the replication checkpoint and the S-phase DNA damage checkpoint.

Mrc1 (mediator of replication checkpoint) was discovered by screening for mutations that cause hydroxyurea sensitivity and are rescued by overproduction of the replication checkpoint kinase Cds1/Chk2 (Tanaka and Russell 2001).

However, the precise molecular mechanisms by which stalled forks activate the replication checkpoint are not completely understood.

First, Mrc1p functions in the replication checkpoint by mediating the DNA damage signal from the sensor Mec1p to the checkpoint kinase Rad53p.

Since Swi1 Swi3 is required for the chromatin association of Mrc1, which is essential for Cds1 activation [52], Swi1 Swi3 may regulate the replication checkpoint pathway by recruiting Mrc1 to activate Cds1 and promote fork stabilization in response to HU (Figure 8).