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The diagnoses were confirmed by the reference pathologists of the Lymph Node Registry Kiel on the basis of standard histopathology and appropriate immunohistochemical stainings using the alkaline phosphatase-anti-alkaline phosphatase (APAAP) technique with mouse monoclonal antibodies.
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Thereafter, the categorization was compared with the diagnosis provided by the reference pathologist.
Thereafter, the treating clinicians are informed about the diagnosis by the reference pathologist respectively the consensus diagnosis.
The pathological characteristics recorded by the reference pathologist, and information on staging, are displayed in Table 2-wrap>.
The result of pathological assessment by the first, local pathologist is communicated to the treating clinician, but for treatment decision also the diagnosis by the reference pathologist is included.
For reasons of quality assurance, all participating pathologists received a training set of histological slides, provided by the reference pathologist that contains 20 cases of all kinds of breast pathologies.
However, the reference pathologist was not blinded against local pathologists.
AS is the reference pathologist for confirmation of histological diagnosis.
RO served as the reference pathologist and reviewed all patient samples.
The diagnosis of MCL was verified by two reference pathologists from the European Mantle Cell Lymphoma Network (MT and RP).
All tumours were reviewed by pathologists at the institution from which the samples were acquired or by central reference pathologists (Supplementary Table S1 and Supplementary Materials).
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