Sentence examples for by the proteolytic processing from inspiring English sources

Amyloid-β peptide species ending at positions 40 and 42 (Aβ40, Αβ42) are generated by the proteolytic processing of the Alzheimer's amyloid precursor protein (APP).

To test the hypothesis that the extinction of fear memories is mediated by the proteolytic processing of proBDNF, the synthetic competitive inhibitor of tPA, tPA-STOP (2,7-bis-4 amidino-benzylidene -cycloheptanone-1-dihydochloride 2,7-bis-4 amidino-benzylidene -cycloheptanone-1-dihydochloride 2,7-bis-4 amidino-benzylidene -cycloheptanone-1-dihydochloride 2,7-bis-4 amidino-benzylidene -cycloheptanone-1-dihydochloride 2,7-bis-4 amidino-benzylidene -cycloheptanone-1-dihydochloride 2,7-bis-4 amidino-benzylidene -cycloheptanone-1-dihydochloride 2,7-bis-4 amidino-benzylidene -cycloheptanone-1-dihydochloride

IN is formed by the proteolytic processing of the viral Gag-Pro-Pol precursor.

Caspase-3, a marker for cells that undergo apoptosis, is activated by the proteolytic processing of its inactive zymogen into the activated p17 and p12 fragments, respectively.

Moreover, they demonstrated that the endothelial-repelling function of Sema3E pre-exists to, and it is not significantly blocked by, the proteolytic processing of the molecule.

The non-canonical pathway is primarily characterized by the proteolytic processing of p100 subunit leading to the formation of p52 fragment in a NIK-dependent manner (Dejardin, 2006).

A new mechanism of cyclin E deregulation recently described by our group is the proteolytic processing of full-length cyclin E at two sites in the amino-terminus by an elastase-like protease, independently of proteasome-mediated proteolytic degradation [ 10, 11].

If so, this would represent a novel mechanism for regulating the density and distribution of different subsets of neurites within the tissue they innervate that is governed by regional differences in the proteolytic processing and/or secretion of precursor and mature forms of the same factor rather than on regional differences in the synthesis of different neurotrophic factors.

These are all components of the human γ-secretase complex which completes the proteolytic processing by releasing the Aβ peptide at its C-terminal end from the Alzheimer's Precursor polypeptide [ 36].

The proteolytic processing (exerted by, for instance, cathepsin K) excises part of an exposed loop region close to the active site and is permissive for the catalytic activation of TRAP [13].

The proteolytic processing of polyproteins by the 3CL protease of severe acute respiratory syndrome coronavirus is essential for the viral propagation.