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Dose intensity was defined as the actual dose administered divided by the planned dose.
The relative dose intensity was calculated by dividing the actual dose intensity by the planned dose intensity.
Dose intensity was calculated as the total delivered dose divided by the planned dose, for each agent.
Relative dose intensity was calculated as the dose intensity divided by the planned dose intensity, multiplied by 100.
Median dose intensities (i.e. the actual dose administered divided by the planned dose) were 80.0% for irinotecan, and 78.9% for capecitabine.
The mean relative dose intensity was calculated by dividing the delivered dose (mg m−2 week−1) by the planned dose (mg m−2 week−1) for the number of cycles each patient received.
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Implementation of a risk model can provide better data by making the planned dose closer to the delivered dose, and the impact of dose can be measured more accurately.
The dose intensity per cycle was calculated as the relationship of delivered by the planned doses from treatment start multiplied by the ratio of planned vs actual treatment days.
The dose of cisplatin in subsequent cycles was reduced by 25% from the planned dose if there were grade 4 haematologic toxicities or if grade 2 renal toxicity.
The dose of irinotecan in subsequent cycles was reduced by 25% from the planned dose if there were any grade 4 hematologic toxicities lasting more than 7 days, ⩾grade 3 haematologic toxicities with febrile episode, or bleeding-associated thrombocytopenia.
Cisplatin was discontinued if creatinine clearance fell below 45 ml min−1 or in case of neurotoxicity >grade 2. The planned dose intensity was calculated by dividing the planned total dose of cisplatin (mg m−2) by the planned duration of treatment given in weeks (i.e. 6 weeks for cisplatin single agent and 7 weeks for cisplatin in combination with etoposide or paclitaxel).
More suggestions(15)
by the cumulative dose
by the actual dose
by the combined dose
by the planned intervention
by the heavy dose
by the planned mg
by the pediatric dose
by the standard dose
by the planned remodelling
by the full dose
by the last dose
by the fractionated dose
by the planned infrastructure
by the planned reduction
by the specific dose
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