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The severity of pancreatic damage was graded by the pathologist using scoring criteria according to references [ 16].
The centroblast count is performed manually by the pathologist using an optical microscope and hematoxylin and eosin (H&E) stained tissue section.
Firstly, the CB count is performed manually by the pathologist using an optical microscope on hematoxylin and eosin (H&E) stained tissue sections, which leads to subjectivity.
Each lesion was described by the pathologist using gross and histological examination and the severity of the internal lesion was compared with the clinical presentation.
Even in the absence of an accurate measure of tumour size by the pathologist using imaging at diagnosis, it should thus be possible in most patients to gain an accurate assessment of initial tumour size.
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These slides were used for determining the stages of fibrosis by a pathologist, using the five-point METAVIR scoring system (F0-F4) [ 7].
The tumor and normal areas were diagnosed by a pathologist using the H&E matched slide and microdissected to pinpoint the tumor and normal areas from at least two slides.
The FDPS staining was scored by a pathologist using the criteria described in Supplementary Methods.
The sections were reviewed and scored blindly by a pathologist using the classification criteria described below.
The samples were examined by the same pathologists using the dating criteria described by Noyes et al. (1975).
All patients included in the study had received liver biopsies that were evaluated by one pathologist using the Metavir scoring system.
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