The absence of Lewy bodies in the SMP precludes affirmation that the SMP is intrinsically affected by the pathological process.
In these cases, however, the influence of good technique is limited by the pathological process.
These networks overlap extensively with networks targeted by the pathological process in FTLD.
The maintained precision in firing will provide clues as to the types of ion channels which might be impacted by the pathological process.
Both insula and thalamus are involved by the pathological process in FTLD (Chow et al., 2008; Zhou et al., 2010; Garibotto et al., 2011).
The birthweight of babies born prematurely is likely to be influenced by the pathological process leading to preterm birth and therefore likely to differ from those remaining in utero until term [ 25, 26].
For further molecular analyses of αSD, we designed an ELISA test that identifies αSD specifically in sick mice and in the brain regions targeted by the pathological process in this mouse model.
Thus, despite IPF being a disease of peripheral lung, these observations raise the possibility that neurotrophins, generated by the pathological process of usual interstitial pneumonia, occur in more central airways where they may influence neuronal proliferation and differentiation.
All together, our data show clear ELISA differentiation between sick and healthy mice, and between brain regions differently affected by the pathological process, thereby demonstrating that the ELISA approach specifically recognizes disease-associated αS.
Considering the PI-related cortical thickness alterations in the regions showing abnormal structural covariance, we could speculate that the increased or decreased connectivity may reflect a correlative or inverse cortical thickness changes due to enhanced mutual or inhibitory interregional trophic/functional relationship, as affected by the pathological process of PI.
