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Therefore, future studies to determine whether aberrant dsRNA formation causes, or is caused by, the pathological mislocalization of TDP-43 are paramount.
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This truth gets obscured by the pathological level of partisanship within our political culture.
This idea is supported by the mislocalization of Sun2 in Lmna−/− MEF cells [54], [59].
Synthesis of PspA protein is induced by the mislocalization of some outer membrane proteins, especially secretins (reviewed by Model et al [23].
This can lead to altered microtubule assembly dynamics, highlighted by the mislocalization of the mitotic kinesin Eg5 in breast cancer cells (7).
crb mutant embryos, which do not express any Crb protein, showed aberrations already in the initial invagination process at early stage 11, as revealed by the mislocalization of the ZA marker Cno, the Drosophila ortholog of mammalian Afadin.
The pathological evaluation indicated the liver and kidney were damaged by CCl4.
It makes the pathological ordinary.
By contrast, the mislocalization of Crb onto the basolateral membrane of ept mutant cells is either stat92E-independent or less sensitive to a two-fold reduction of stat92E dosage.
Mutation of both arginine residues (R10E/R12E) in the motif resulted in the mislocalization of SOAT from the ER as monitored by sucrose density fractionation.
Females with the BicD2 allele produce embryos with defective anterior structures [24], [25] caused by a partial mislocalization of osk mRNA to the anterior of the oocyte and the embryo [26], [27].
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