Sentence examples for by the pathological aggregation from inspiring English sources

Tauopathies, a class of neurodegenerative diseases including Alzheimer's disease, frontotemporal dementia, and progressive supranuclear palsy, are characterized by the pathological aggregation of hyperphosphorylated tau tangles in the human brain [ 1].

Islet amyloidosis, caused by the pathological aggregation of human islet amyloid polypeptide (IAPP, amylin) in the pancreatic islets of Langerhans, contributes to β-cell dysfunction in type 2 diabetes.

A characteristic of several aggregation inhibitors represents their ability to block the pathological aggregation of other proteins like Aβ and α-synuclein [ 34].

A number of studies have suggested that the helix-rich membrane bound form of α-syn plays a crucial role in initiating the pathological aggregation of the protein.

Several neurodegenerative disorders are characterized by pathological aggregation of the axonal protein Tau into "neurofibrillary tangles" classifying them as tauopathies [ 1].

This favors the notion that pathological aggregation processes (mimicked e.g., by VHL and Rnq1 over-expression) can hijack endogenous proteostasis regulatory mechanisms, possibly underlying their harmful effects in cells (Park et al., 2013).

Here we investigate the growing body of evidence demonstrating the ability of αsyn to spread transcellularly and induce pathological aggregation affecting neurons by permissive templating and provide a critical analysis of some irregularities in the hypothesis that the progression of PD pathology may be mediated by such a prion-like process.

In Alzheimer's disease, accumulation and pathological aggregation of amyloid β-peptide is accompanied by the induction of complex immune responses, which have been attributed both beneficial and detrimental properties.

However, the ability to bind target RNA, which is a prerequisite for physiological aggregation of TDP-43, FUS and related proteins (45, 46), is not compulsory for their pathological aggregation as illustrated by our recent studies of FUS in cells and transgenic mice (23, 24).

Our observations suggest that pathological aggregation of γ-synuclein might contribute to the pathogenesis of ALS.

Pathological aggregation of TDP-43 is regulated by both N-terminal and C-terminal regions, but also includes modifications like truncation, ubiquitination and phosphorylation [ 16, 29- 32].