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The phylogeographic structure within Z. capensis was initially assessed by constructing a median-joining network using the CR dataset and NETWORK v4.6.1.0 (Fluxus Technology, Lt).. Differentiation between lineages identified by the network analysis was measured using ΦST values calculated with ARLEQUIN v3.5.1.2 [ 41] and average p distances using MEGA v5 [ 42].
This partition in two time frames is also confirmed by the network analysis.
The genes we identified as steatosis-associated by the network analysis (Figure 4, Figure 5), such as ACOX1, SCD, PPARγ, CFD and CIDEC were re-discovered by the regression analysis.
This synchronous swap of the major functional signatures between the early and the late phase and the fact that the key controllers of the reciprocally regulated processes (as revealed by the network analysis (Figure 4, Figure 5)) are implicated in the mutual repression suggest that the regulatory exchange may occur via tightly controlled reactions, limited to few master regulators.
We validate our predictions generated by the network analysis using Cd44 knockout mice.
(see Discussion below), this may be primarily due to ancient hybridization as indicated by the network analysis.
Similar(44)
Therefore, CVDHD can be applied seamlessly to the network pharmacology analysis by using the network analysis software such as Cytoscape and CentiBin.
By introducing the network analysis, in Eq. (1), the equation will be improved from geographic distance to real travel distance, time, or cost based on the transportation network.
However by performing the network analysis it clearly comes out as a major hub suggestive of an important role during lactose diauxic shift which actually is in agreement with previously published findings [31].
Fuhrman and Steele (2008) extended the analysis by focusing the network analysis on what they called "nearest neighbors" (organisms or factors that correlate directly either positively or negatively with one another).
The identification of this cascade of gene regulation was possible by combining the network analysis with the functional information available at EcoCyc.
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