Sentence examples for by the modified comet from inspiring English sources

Red cell folate was negatively correlated with DNA damage detected by the modified comet assay (using FPG enzyme).

There was a significant negative correlation between RCF values and DNA damage detected by the modified comet assay using FPG enzyme.

In breast cancer patients who had high RCF values, there was a significant positive correlation between log alcohol intake and log tail moment detected by the modified comet assay (Endo III) (Pearson Correlation Coefficient=0.67, P=0.01) and log tail moment detected by the modified comet assay (FPG) (Pearson Correlation Coefficient=0.58, P=0.04).

A similar pattern was observed in samples processed by the modified comet assays, with a larger percentage of cells showing higher tail moment values in breast cancer than control patients.

In breast cancer patients who had low RCF values, there was a significant positive correlation between log alcohol intake and log tail moment detected by the modified comet assay (FPG) (Pearson Correlation Coefficient=0.58, P=0.04).

Alcohol intake was positively correlated (independent of folate status) with the level of DNA damage detected by the modified comet assay in breast cancer, but not the control patients.

The mean tail moment (s.d). of DNA damage in MNC of breast cancer patients detected by the basic comet assay was 1.4 (0.66) vs –0.17 (0.79) in controls (P<0.0001, t-test), the modified comet assay 'endonuclease III (Endo III)' was 1.7 (0.70) vs 0.86 (0.81) (P<0.0001, t-test), and the modified comet assay 'formamidopyrimidine glycosylase (FPG)' was 1.6 (0.62) vs 0.99 (0.94) (P<0.0001, t-test).

Chloral hydrate, hydroquinone, sodium iodoacetate, mitomycin C and thimerosal were also tested in the modified comet assay using lysed cells.

DNA damage biomarkers were measured in the MNC using the alkaline comet assay (Singh et al, 1988) and the modified comet assay (Collins et al, 1993) as described below.

After exposure for 24 h the cells were washed with PBS then detached by trypsinization (0.25% porcine trypsin in 2% EDTA (Sigma-Aldrich, USA)), centrifuged, resuspended in 100  μL of PBS, and analysed by Fpg modified comet assay immediately to evaluate simultaneously direct and oxidative DNA damage.

In this study, the levels of DNA damage detected by basic and modified comet assay were significantly higher in breast cancer patients than controls.