This overrepresentation cannot be explained by the modest difference in nucleotide composition between these regions, consistent with the comparable distribution in the randomly simulated datasets (Table 1).
In addition, as suggested by the sponsor, the modest differences seen in serum sodium may have been partially a result of a conservative dose titration scheme.
The three SNPs we found associated with vitamin D levels and with clinical deficiency to some extent, along with nearby variants in LD with them, could be included in studies of Mendelian randomization of vitamin D status and disease outcomes, although the modest differences by number of minor alleles suggest that very large sample sizes would be needed to confirm the expected small associations.
The modest differences varied by biomarkers and were highest for MEHP [percent difference = 29%; 95% confidence interval (CI): 8, 55%] and lowest for BPA (percent difference = 6%; 95% CI: –4, 17%).
In other words, with similar prevalences of all but pMOH, the modest differences in headache-attributed burden can be explained by geographical, cultural and environmental differences between these two countries.
The modest differences in hemostasis markers did not explain the large age-related differences in mortality.
By contrast, the modest difference observed in M. marinum number suggests that, in a more complex, chronic infection, MEF2 is also important in tolerance of pathology.
These small differences in neurite growth cannot be accounted for by the known modest differences in neuronal survival between wild-type and p75NTR-deficient postnatal SCG neurons (Lee et al., 1994b), because Boc-D-FMK was included in the medium to ensure similar levels of survival in all cultures (confirmed by cell counts, not shown).
The more modest differences between adult and neonatal effector cells were masked by the large expression differences in naive cells.
The alternative splicing affects the enzyme regulation by phosphorylation, but only modest differences in the catalytic properties of the isoforms have been reported [Haavik et al., 1991; Nasrin et al., 1994; Gordon et al., 2009].
