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This difference is most likely explained by the methodological variations, regional characteristics in marketed product ranges and by differences in classifying excipients into the toxicity categories.
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The authors conclude that in gastric carcinomas the prediction of response to chemotherapy on the basis of relative tumour SUV changes is not essentially influenced by any of the methodological variations investigated (incubation period 40 or 90 min, reconstruction method FBP or OSEM and various SUV normalizations).
The minor variations in the predictions might reflect the methodological variations followed by different programs to identify signal peptides.
This high discrepancy is mainly due to the methodological variations.
The methodological variations were also evident for the top 20 most abundant miRNAs (Table 2).
These differences may be explained by methodological variations in the in vitro models used, suggesting that HAM was more affected by the experimental conditions.
Conflicting findings across studies might be explained by methodological variations and by particular characteristics of the studied populations.
The discrepant results of clinical follow-up studies are best explained by substantial methodological variations, study populations of insufficient size, and short periods of clinical follow up.
Non-vertebral fractures are infrequent events; their use as a trial endpoint requires large or high-risk populations and is affected by methodological variations (Miller 2008).
Future research could advance this line of inquiry by using other methods of analyses (e.g., area under the curve; AUC), in order to better understand the effects of methodological variations and their implications for research design.
For the analysis of specific gene families, methodological variations were introduced as reported in text.
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