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As in prior studies, efficacy was assessed by the mean change from baseline in IDS-C30 total score.
If there were data for < 10 days in the diary, including for those who withdrew from the study, the number of headache days for the missing period was imputed by mLOCF based on the patient's previous 28-day diary period and adjusted by the mean change observed in all patients with diary records for the same periods.
The effect size (ES) was calculated by the mean change of the score/SD.
First, cut-points were estimated by the mean change or mean score approach (de Vet et al. 2011).
Blood pressure control will also be evaluated by the mean change in blood pressure parameters (systolic, diastolic, mean arterial, and pulse pressure).
The primary objective was to assess the effect of atomoxetine on patients with ADHD+D as measured by the mean change from baseline on the ADHDRS-IV.
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The standardized response mean preserves the relation to a statistical test, and is calculated by dividing the mean change by the standard deviation of the change.
The effect size anchors the changes against the variability in the sample, and is calculated by dividing the mean change by the standard deviation at baseline.
SRMs are derived by dividing the mean change score by the pooled standard deviation [ 41].
SRMs were calculated by dividing the mean change scores by the standard deviation (SD) of the change scores.
The ability of a measure to assess change is quantified by dividing the mean change (signal) by the variation in change or sample characteristics at baseline (noise).
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