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Contrary to the in vivo model, where dying cells appear to be cleared from the circulation by the liver, the human blood ex vivo model represents a different microenvironment whereby biological processes and related measurements could be affected by artifacts such as increased DNA fragmentation and apoptosis, that could be a confounding factor in the day 3 cultures.
There are two phases by which toxins are cleared by the liver -- the first phase makes the toxins more water soluble and the second phase packages them up so they can be excreted from the body.
While the plasma vitronectin is produced mainly by the liver, the origin of the tissue vitronectin is less clear [8].
In the case of ICG which is exclusively removed by the liver, the intravenous infusion rate equals the rate of hepatic removal.
Although ip injection bypasses first pass metabolism of the DMP by the liver, the absence of any adverse effects is reassuring.
In addition to the production of bile by the liver, the gall bladder may be able to further regulate the sterol content of bile, via ABCG5/ABCG8 activity.
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The SPIO tracer is well tolerated and metabolized by the liver and the spleen.
Instead, the brain is fed the ketone bodies produced by the liver as it processes the body fat.
Other substances, including certain drugs, also are removed from the plasma by the liver.
CRP is produced by the liver, and the levels rise when there is inflammation throughout the body.
Globally, the most commonly transplanted organs are the kidneys, followed by the liver, heart and lungs.
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